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KMID : 1040620150210010032
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Clinical and Molecular Hepatology
2015 Volume.21 No. 1 p.32 ~ p.40
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The factors associated with longitudinal changes in liver stiffness in patients with chronic hepatitis B
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Yo In-Ku
Kwon Oh-Sang
Park Jin-Woong
Lee Jong-Joon
Lee Jung-Hyun
Won In-Sik
Na Sun-Young
Jang Pil-Kyu
Park Pyung-Hwa
Choi Duck-Joo
Kim Yun-Soo
Kim Ju-Hyun
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Abstract
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Background/Aims: Liver stiffness (LS) as assessed by transient elastography (TE) can change longitudinally in patients with chronic hepatitis B (CHB). The aim of this study was to identify the factors that improve LS.
Methods: Between April 2007 and December 2012, 151 patients with CHB who underwent two TE procedures with an interval of about 2 years were enrolled. Ninety-six of the 151 patients were treated with nucleos(t)ide analogues [the antiviral therapy (+) group], while the remaining 55 patients were not [the antiviral therapy (?) group]. The two groups of patients were stratified according to whether they exhibited an improvement or a deterioration in LS during the study period (defined as an LS change of ≤0 or >0 kPa, respectively, over a 1-year period), and their data were compared.
Results: No differences were observed between the antiviral therapy (+) and (?) groups with respect to either their clinical characteristics or their initial LS. The observed LS improvement was significantly greater in the antiviral therapy (+) group than in the antiviral therapy (?) group (?3.0 vs. 0.98 kPa, P=0.011). In the antiviral therapy (+) group, the initial LS was higher in the LS improvement group (n=63) than in the LS deterioration group (n=33; 7.9 vs. 4.8 kPa, P<0.001). However, there were no differences in any other clinical characteristic. In the antiviral therapy (?) group, the initial LS was also higher in the LS improvement group (n=29) than in the LS deterioration group (n=26; 8.3 vs. 6.5 kPa, P=0.021), with no differences in any other clinical characteristic.
Conclusions: A higher initial LS was the only factor associated with LS improvement in patients with CHB in this study.
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KEYWORD
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Chronic hepatitis B, Hepatic fibrosis, Liver stiffness, Transient elastography
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